366 500 injections later

Bio016295 359..366

Here we genetically characterise pelvic finless, a naturally occurring model of hindlimb loss in zebrafish that lacks pelvic fin structures, which are homologous to tetrapod hindlimbs, but displays no other abnormalities. Using a hybrid positional cloning and next generation sequencing approach, we identified mutations in the nuclear localisation signal (NLS) of T-box transcription factor 4 (Tb...

Bez nazwy-366

366 - 372 Fung SY.pmd

The protective effects of Mucuna pruriens seed extract (MPE) against the cardio-respiratory depressant and neuromuscular paralytic effects induced by injection of Calloselasma rhodostoma (Malayan pit viper) venom in anaesthetized rats were investigated. While MPE pretreatment did not reverse the inhibitory effect of the venom on the gastrocnemius muscle excitability, it significantly attenuated...

M399_27b 362..366

362 NATURE | VOL 399 | 27 MAY 1999 | www.nature.com lateral interactions may allow basilar membrane motion to be selectively enhanced at a particular location where passive vibration is maximal. In nonlinear systems, 10% feedback can have enormous consequences. The likely increase in OHC coupling with increasing frequency, supported by morphological evidence, may explain the finding that tuning...

Npgrj_nn_2049 360..366

Cortical layering is a hallmark of the mammalian neocortex and a major determinant of local synaptic circuit organization in sensory systems. In motor cortex, the laminar organization of cortical circuits has not been resolved, although their input-output operations are crucial for motor control. Here, we developed a general approach for estimating layer-specific connectivity in cortical circui...